HPE Expands ProLiant Gen12 Server Portfolio, Helps Customers Modernize Virtualization and Edge Computing With AI-Driven Management

In this article

• HPE debuts two new HPE ProLiant Compute Gen12 servers with 5^th Gen AMD EPYC™ processors designed for virtualization, VDI and container workloads and deliver 2X the memory compared to the previous generation.
• New automated management features, including AI-driven capabilities delivered through HPE Compute Ops Management, enable greater IT visibility, security, and control.
• Expanded virtualization choice through HPE Morpheus VM Essentials Software reduces operational complexity and simplifies multi-hypervisor management.
• Expanded support for virtualization at the edge delivered through the HPE ProLiant DL145 for Microsoft Azure Local Integrated System.

LAS VEGAS--(BUSINESS WIRE)--HPE Discover Las Vegas 2025 – HPE (NYSE: HPE) today announced an expansion to the HPE ProLiant Compute Gen12 server portfolio, which delivers next-level security, performance and efficiency. The expanded portfolio includes two new servers powered by 5^th Gen AMD EPYC processors to optimize memory-intensive workloads, and new automation features for greater visibility and control delivered through HPE Compute Ops Management.

In addition, HPE ProLiant Compute servers are now available with HPE Morpheus VM Essentials Software support. HPE Morpheus VM Essentials is an open virtualization solution that helps reduce costs, minimize vendor lock-in, and simplify IT management. HPE also announced new HPE for Azure Local solutions with the HPE ProLiant DL145 Gen11 server to empower expansion of purpose-built edge capabilities across distributed environments.

“Enterprise workloads are growing and evolving, requiring next-generation technologies that maximize IT environments, securely and efficiently,” said Krista Satterthwaite, senior vice president and general manager, Compute at HPE. “The enhanced HPE ProLiant Compute Gen12 portfolio, which now includes new servers powered by 5^th Gen AMD EPYC processors, drives even greater optimized workload performance, security protection from the chip-to-the-cloud, and a boost to productivity with AI-driven management capabilities.”

HPE delivers double the memory with new HPE ProLiant Gen12 servers

HPE added two new servers to the HPE ProLiant Gen12 portfolio: the HPE ProLiant Compute DL325 and DL345 Gen12 servers with latest AMD EPYC processors.

The new servers are optimized to handle memory-intensive workloads, such as virtualization and edge deployments, with twice as much memory – up to 6TB – compared to the previous generation.¹

The new servers feature the next generation HPE Integrated Lights-Out (HPE iLO 7), HPE’s industry-leading security IP that builds in protection at the silicon level to protect against threats.

The latest version now safeguards the server at the factory floor during assembly to continue all the way through a server’s end-of-life and includes protection against future quantum computing attacks.

Simplifying management and boosting productivity with enhanced automation features through HPE Compute Ops Management

HPE also announced new automated and AI-driven features for HPE Compute Ops Management, a secure, cloud-based software application to monitor and manage servers.

Available on all HPE ProLiant Compute Gen12 servers, these new features offer customers a number of benefits across their environment:

• Enhanced insights – New tool allows customers to view HPE Active Health System files within HPE Compute Ops Management to expedite root cause analysis, avoid opening support tickets, and greatly reduce mean time to resolution
• Reduced complexity – Seamless integration of multi-vendor server monitoring into existing environments to help simplify operations, decrease the number of tools required for daily activities and achieve a consolidated view of the entire compute infrastructure
• Decreased downtime – Gain AI-driven insights with workflow policy approvals to safeguard against major disruptive operations often caused by human error. Latest feature ensures that policies are verified and necessary layers of action approval are in place to prevent downtime

HPE Compute Ops Management is already helping customers simplify server management, dramatically reducing manual effort in deployment. Improvements include²:

• Up to 75% less time spent managing servers
• Up to 4.8 hours less downtime per server per year
• Up to $152,000 in travel and software costs saved over three years

Modernizing and optimizing costs with HPE Morpheus VM Essentials Software

HPE is further simplifying IT management for customers by enabling HPE Morpheus VM Essentials Software on the latest HPE ProLiant servers. With the virtualized solution, customers can achieve higher performance for virtualized workloads while saving space and energy, and reducing licensing costs by up to 90 percent.³

HPE ProLiant Compute Gen12 servers featuring AMD EPYC™ processors offer performance and power efficiency with HPE Morpheus VM Essentials.

Additional details can be found here: Driving Virtualization Forward: The Power of AMD and HPE Morpheus VM Essentials Software

Empowering virtualization at the edge with seamless integration through the HPE ProLiant DL145 for Azure Local Integrated System

Additionally, HPE announced that the HPE ProLiant DL145 Gen11 server, engineered for the edge and featuring AMD EPYC processors, is now available as an HPE Integrated System for Azure Local for seamless integration between on-premises infrastructure and cloud services.

The HPE ProLiant DL145 Gen11 server is compact, resilient, quiet, and adaptable to fit on any tabletop, wall, or cabinet, making it ideal for any edge environment across retail, financial services, manufacturing, and healthcare.

The server is easy to deploy with plug-and-play installation and blends in seamlessly in a customer’s environment while delivering high performance for data processing and real-time insights.

The HPE ProLiant DL145 Gen11 servers also offer HPE Compute Ops Management to securely access, monitor, and manage servers, no matter where they live, and are pre-configured with the latest software and security updates to deploy systems quickly.

Availability

HPE ProLiant DL145 for Azure Local Integrated System is available today.

HPE ProLiant Compute DL325 and DL345 Gen12 servers are available for order today and will ship in July.

HPE Morpheus VM Essentials software is available today.

Latest compute solutions from HPE will be showcased at HPE Discover Las Vegas 2025.

About HPE

HPE (NYSE: HPE) is a leader in essential enterprise technology, bringing together the power of AI, cloud, and networking to help organizations achieve more. As pioneers of possibility, our innovation and expertise advance the way people live and work. We empower our customers across industries to optimize operational performance, transform data into foresight, and maximize their impact. Unlock your boldest ambitions with HPE. Discover more at www.hpe.com.

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¹ Based on comparison between HPE ProLiant Compute DL325 and DL345 Gen11 servers using 5th Gen AMD EPYC processors with up to 3TB memory.

² Based on customer feedback study from Forrester Consulting, New Technology: The Projected Total Economic Impact™ of HPE Compute Ops Management, commissioned by HPE (June 2024) https://www.hpe.com/psnow/doc/a00141308enw

³ Based on internal analysis of the cost of HPE Morpheus VM Essentials licensing versus available market data on cost of existing virtualization licensing. Savings do not include discounts and subject to change without notice.