CalmWave Closes Oversubscribed $4.4 Million Follow-On Investment from Third Prime, Bonfire Ventures, Catalyst by Wellstar, and Silver Circle to Transform Hospital Operations

SEATTLE--(BUSINESS WIRE)--CalmWave, creator of the Calm ICU™ and leader in eliminating non-actionable alarms through healthcare data science and Transparent AI, today announced a $4.4 million follow-on round from current investors Third Prime, Bonfire Ventures, Catalyst by Wellstar, and Silver Circle. The capital will be used to further accelerate market penetration driven by strong demand from hospital systems.

“We've done what many believed impossible and shown significant reductions in non-actionable alarms, a key driver of ICU alarm fatigue – and this pre-emptive and oversubscribed round is recognition of this achievement,” said Ophir Ronen, founder and CEO, CalmWave. “Our pilot with Wellstar demonstrated that our platform is effective at fusing disparate healthcare data silos and using Transparent AI to enable clinicians to reduce non actionable ICU alarms. The demand is clear, and we are scaling our game-changing hospital operations platform to a rapidly growing list of healthcare systems.”

“CalmWave embodies exactly the kind of founder-led innovation we back – a mission-driven team tackling one of healthcare’s most stubborn problems with clarity, grit, and a truly novel approach,” said Keith Hamlin, Partner at Third Prime. “Their success with Wellstar shows what’s possible when Transparent AI is applied with precision and purpose. We’re proud to support CalmWave as they scale a future where the ICU is not just smarter but Calm.”

The First-Ever Effective Solution to Alarm Fatigue

CalmWave is the first effective solution to address the endemic problem of alarm fatigue in Intensive Care Units (ICUs). Non-actionable alarms are alerts triggered by monitoring systems that do not require immediate intervention or clinical response. These alarms make up 80-99% of alarms in ICUs and are the primary cause of alarm fatigue, which occurs when the constant flood of alarms overwhelms both clinicians and patients. This barrage of alarms not only heightens the risk of negative outcomes like ICU delirium, but it also strains healthcare staff, impacting overall patient care. The Calm ICU™ is a signal-led critical care environment, powered by CalmWave, where non-actionable noise is cut and clinical urgency breaks through. It’s how hospitals align teams, technology, and time to accelerate decisions where they matter most: at the bedside.

Transparent AI Empowers Clinicians to Make Data-Driven Decisions

The CalmWave Operations Platform uses "Transparent AI," which makes the reasoning and data behind its conclusions both visible and fully understandable to users. This approach empowers healthcare organizations to optimize operations and confirm they are making well-informed, data-driven decisions. To feed its models, CalmWave uses a hospital’s retrospective and real-time patient data, such as vital signs, interventions, and medication administration, to provide objective recommendations for reducing alarm fatigue. Implementing these recommendations by nursing staff improves the clinical work environment and patient care.

CalmWave’s platform is built on an AI-first architecture, where artificial intelligence serves not as an added layer but a foundational principle. By embedding AI in all modalities, starting with Machine Learning, CalmWave ensures that every function, from alarm reduction to clinical operations, is powered by transparent models engineered specifically for complex healthcare environments. This AI-first approach enables the platform to rapidly ingest real-world data and adapt to varied hospital data ecosystems, providing predictive insights and scalable optimization. This focus reinforces CalmWave’s commitment to building intelligent systems that continuously learn, support frontline teams, and elevate clinical performance while reducing operational and cognitive burden.

About CalmWave

CalmWave's mission is to objectively improve healthcare, starting with safely eliminating non-actionable alarms. Alarms triggered by bedside monitoring systems that do not require immediate intervention or clinical response comprise 80-99% of all audible alarms in intensive care units (ICUs). They contribute to a well-recognized and widespread issue known as alarm fatigue, endemic to every hospital worldwide. Alarm fatigue, rampant in the modern healthcare system, causes great stress for clinicians and patients, ultimately impacting patient outcomes and staff retention. Using Transparent AI, CalmWave outlines the rationale behind each optimized setting, empowering a hospital’s clinical staff to evaluate and implement optimized alarm limit recommendations in the bedside monitor at the patient’s bedside using the CalmWave Operations Platform, which integrates seamlessly with the hospital’s EMR. Doing so remediates alarm fatigue and can improve staff retention and patient outcomes. Visit CalmWave.ai for more information and follow us on LinkedIn and X.